Some diseases, including periodontal diseases as well as anesthesia and drugs, can increase oxidative stress in the body which causes the destruction of cells. Therefore, the effect of tramadol and meloxicam as the two frequently used analgesic drugs on the induction of oxidative stress was investigated in this study. 30 dogs affected with advanced periodontitis which is candidates for dental extraction under general anesthesia were assigned to two different groups randomly. After induction of anesthesia group A received meloxicam (0.2 mg/kg, IV) and group B received tramadol (3 mg/kg, IV) as an analgesic. Prior to injection, at 30 minutes and 60 minutes, and 3 hours after the induction of anesthesia blood samples were collected to measure indicators of oxidative stress including Malondialdehyde (MDA), Superoxide Dismutase (SOD), and Total Antioxidant Capacity (TAC). As a result, an increase in all indicators of oxidative stress was observed at different times measured in both groups. However, the increase was more evident in group B. A significant difference in meanSD increase of MDA and decrease of SOD at 30, 60 min, and 3 hours after the injection was observed between the groups. In conclusion, meloxicam provided fewer imbalances on oxidative stress and therefore, has beneficial effects in dental extractions due to advanced periodontitis in dogs, which is very probable done by regulating the inflammatory and oxidation factors.