Iranian Journal of Veterinary Surgery

Iranian Journal of Veterinary Surgery

Evaluation of Potential Effect of Bone Marrow Mast Cells on Burn Wound Healing in Rat

Document Type : Original Article

Authors
Shima Mousazadeh 1
Amir Amniattalab 1
Rahim Mohammadi 2
1 Department of Pathology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.
2 Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
10.30500/ivsa.2024.446910.1392
Abstract
The objective of this work was to assess the potential effect of bone marrow mast cells (BMMCs) on burn wound healing in rats. We included 45 male rats into three groups of 15 animals each: CNTRL group: We treated the burn wounds with normal saline (0.1 ml). TRTMENT group: In this group, the burn wounds were treated with bone marrow mast cells (1× 106/ml). SSD (Positive control) group: In this group, the wounds were treated with silver sulfadiazine 1% ointment. Wound area reduction measurements, histopathological studies, and biochemical assessments levels showed significant differences between rats in TRTMENT group in comparison with other groups (p < 0.05). Accelerated repair of the wounds in TRTMENT group showed that local application of BMMCs could be taken into consideration in burn wound healing.
Keywords
Burn wound
BMMCs
Rat

Subjects

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  • Receive Date 04 March 2024
  • Revise Date 14 May 2024
  • Accept Date 18 May 2024
  • First Publish Date 18 May 2024