A Case of Cervical Intramedullary Dirofilaria immitis Associated with Nerve Sheath Tumor in a Dog

Nasiribari, Tohid; Akçasız, Zeynep Nilüfer; Eravcı Yalın, Ebru; Öztürk, Necati; Haktanır, Damla; Gülçubuk, Ahmet

doi:10.30500/ivsa.2024.449212.1395

A Case of Cervical Intramedullary Dirofilaria immitis Associated with Nerve Sheath Tumor in a Dog

Document Type : Clinical Report

Authors

Tohid Nasiribari ¹

Zeynep Nilüfer Akçasız ²

Ebru Eravcı Yalın ²

Necati Öztürk ³

Damla Haktanır ³

Ahmet Gülçubuk ³

¹ Institute of Graduate Studies, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa University, Istanbul, Türkiye.

² Department of Surgery, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa University, Istanbul, Türkiye.

³ Department of Pathology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa University, Istanbul, Türkiye.

10.30500/ivsa.2024.449212.1395

Abstract

Dirofilaria immitis, a globally widespread nematode known for its high mortality rate, primarily infests the cardiovascular system, notably the pulmonary artery and right ventricle. However, since 1856, instances of adult heartworm infestation in atypical sites have been documented, including the eye, peritoneal cavity, subcutaneous region, skeletal muscle, systemic arteries, and the central nervous system (CNS). Dirofilariasis often manifests asymptomatically, but severe cases can lead to respiratory and circulatory complications, even sudden death. Migration of D. immitis to the CNS results in symptoms corresponding to the parasite's location rather than typical heartworm signs. Magnetic resonance imaging (MRI) plays a crucial role in diagnosing CNS parasitic infestations, aiding in lesion evaluation and parasite localization. Additionally, malignant peripheral nerve sheath tumors (MPNSTs), originating from Schwann cells, fibroblasts, and perineural cells, are rare neoplasms with high recurrence rates and poor prognoses. While MPNST metastases are infrequent, they have been reported in various animal species and anatomical sites, including the CNS. Here, we present the first documented case of intramedullary D. immitis associated with a nerve sheath tumor in a dog, highlighting the unique intersection of parasitic infestation and neoplastic disease in veterinary medicine.

Keywords

Dirofilaria immitis

Central nervous system

Nerve sheath tumors

Subjects

Surgical Pathology

Kittleson MD. Heartworm infestation and disease (Dirofilariasis). In: Kittleson MD, Kienle RD, eds. Small Animal Cardiovascular Medicine Textbook. St. Louis: C.V. Mosby Co.; 1998:370-401.
Tada I, Sakaguchi Y, Eto K. Dirofilaria in the abdominal cavity of a man in Japan. American Journal of Tropical Medicine and Hygiene. 1979; 28: 988–990.
Otto GF. Occurrence of the heartworm in unusual locations and in unusual hosts. In,Otto GF, ed. Proceedings of the Heartworm symptosium 1974 Auburn. Bonner Springs (KS). VM Publishing Co.; 1975: 6–12
Calvert CA, Rawlings CA.Canine heartworm disease. In Kirk, R.W,ed.Current Veterinary Therapy W.B. Saunders. Philedelphia, London, Toronto, 1983: 348.
Kitagawo H, Ishiao K, Kawokomi M. Cardiopulmonary fonction values before and after heartworm removed in dogs with caval syndrome. American Journal of Veterinary Research. 1991; 52 (1): 126-132.
Rawlings CA. Cardiopulmonary function in the dog with Dirofilaria immitis during infection and after treatment. American Journal of Veterinary Research. 1980; 41: 319-325.
Selby, L.A, Corvin, R.M, Hayes, H.M. Risk factors associated with canine heartworm infection. Journal of the American Veterinary Medical Association. 1980; 176 (1): 33-35.
Stuart, B.P,Hoss, E, Root, C.E. Ischemic myopathy associated with systemic dirofilariasis. Journal of the American Animal Hospital Association. 1978: 14: 36-39.
Blass CE, Holmes RA, Neer TM. Recurring tetraparesis attributable to a heartworm in the epidural space of a dog. Journal of the American Veterinary Medical Association. 1989; 194(6): 787–788.
Shires PK, Turnwald GH, Qualls CW, et al. Epidural dirofilariasis causing paraparesis in a dog. Journal of the American Veterinary Medical Association. 1982; 180(11): 1340–1343.
Luttgen PJ, Crawly RR. Posterior paralysis caused by epidural dirofilariasis in a dog. Journal of the American Animal Hospital Association. 1981: 17(1): 57–59.
Chai O, Shelef I, Brenner O, Dogadkin O, Aroch I, Shamir MH. Magnetic resonance imaging findings of spinal intramedullary spriocercosis. Veterinary Radiology and Ultrasound. 2008; 49: 456-459. doi: 10.1111/j.1740-8261.2008.00407.x
Suzuki S, Uchida K, Nakayama H. The effects of tumor location on diagnostic criteria for canine malignant peripheral nerve sheath tumors (MPNSTs) and the markers for distinction between canine MPNSTs and canine perivascular wall tumors. Veterinary Pathology. 2014; 51(4): 722-736. doi: 10.1177/0300985813501336.
Amirian ES, Goodman JC, New P, Scheurer ME. Pediatric and adult malignant peripheral nerve sheath tumors: an analysis of data from the surveillance, epidemiology, and end results program. Journal of Neuro-Oncology. 2014; 116: 609–616. doi: 10.1007/s11060-013-1345-6
Hruban RH, Shiu MH, Senie RT, Woodruff JM. Malignant peripheral nerve sheath tumours of the buttock and lower extremity. A study of 43 cases. Cancer. 1990; 66: 1253–1265.
Otto G. Occurrence of the heartworm in unusual locations and in unusual hosts. In: Proceedings of the Heartworm Symposium. 1974; 6–8.
Favole P, Cauduro A, Opreni M, Zanzani S, Albonico F, Manfredi M, Cantile C, Lorenzo V. Epidural dirofilariosis in a paraparetic cat: case report of Dirofilaria immitis infection. Journal of Feline Medicine and Surgery. 2013; 15(12): 1160-1164. doi: 10.1177/1098612X13492740