Iranian Journal of Veterinary Surgery

Iranian Journal of Veterinary Surgery

The Effects of Honey, Curcumin, Ginger, Nigella sativa and Their Mixture on the Radial Bone Defect Repair in Rat Model: Histological and Biomechanical Study

Document Type : Original Article

Authors
Mohammad Mahmoudi-Fard
Seyfollah Dehghani-Nazhvani
Behrouz Nikahval
Department of Surgery, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
10.30500/ivsa.2021.262771.1238
Abstract
Honey, curcumin, ginger, and Nigella sativa are known for their antioxidant, immune stimulation properties, and wound healing effects. This study was conducted to determine the effect of these compounds and their mixture on the bone healing of the radial bone defect model in rats. One hundred and ten radial bone defects in 55 healthy male rats were randomly divided into 11 groups (10 rats per group). Groups 1-5 received honey, curcumin, ginger, and Nigella sativa orally by gavage, and groups 6-10 received the same materials locally by rubbing them on the sutured skin. The bone repair effects of these materials were evaluated by histopathology and biomechanical examinations. Using honey, curcumin, ginger, and Nigella sativa exhibited a beneficial effect to promote bone healing in this study. The biomechanical and histopathologic evaluations showed that the honey (oral), the mixture of honey and curcumin (oral), and the mixture of honey and Nigella sativa (topical) groups exhibited significantly better results on the 52nd postoperative day compared to the other groups.
Keywords
Bone healing
Honey
Curcumin
Ginger
Nigella Sativa
Rat

Subjects

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  • Receive Date 25 February 2022
  • Revise Date 15 May 2022
  • Accept Date 28 May 2022
  • First Publish Date 30 May 2022