The Effects of Olive Leaf Extract Ointment on Third-Degree Burn in Rat

Raisi, Abbas; Sefidbaf, Ebrahim; Farjanikish, Ghasem; Esmaeili Fard Barzegar, Peyman; Abbasi, Mohsen

doi:10.30500/ivsa.2021.300189.1275

The Effects of Olive Leaf Extract Ointment on Third-Degree Burn in Rat

Document Type : Original Article

Authors

Abbas Raisi ¹

Ebrahim Sefidbaf ¹

Ghasem Farjanikish ²

Peyman Esmaeili Fard Barzegar ¹

Mohsen Abbasi ³

¹ Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

² Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

³ Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

10.30500/ivsa.2021.300189.1275

Abstract

Due to the prevalence of burns and the necessity of effective treatment with low and optimal complications, in the present study, the efficacy of olive leaf extract ointment was evaluated as a therapeutic substance for burn wounds. Moreover, the healing effects of olive leaf extract ointment were compared to Silver Sulfadiazine. 36 rats were used in the present study. To create a burn wound, a rectangular piece of copper (2 x 1 cm) was put in 94º C water for 20 minutes and then placed on the rats’ skin for 30 seconds. Then, the rats were randomly divided into three groups; 1) Sham group: Rats did not receive any treatment and just the wound was washed with distilled water. 2) Control group: In this group rats were treated with silver sulfadiazine. 3) OLE group: 10% olive leave extract ointment was employed to treat the wounds. Wounds were macroscopically examined during days 4, 7, 14, and 21. Histopathological assessments were performed on days 4, 7, 14, and 21 in various studied groups. Results revealed that wound contraction was higher in the OLE group compared to the sham and control groups and histopathological examinations indicated that OLE improved wound healing in comparison to the sham group.

Keywords

Olive Leaf Extract Ointment

Burn

Wound healing

Rat

20.1001.1.20083033.2022.17.1.3.2

Subjects

Laboratory Animals Surgery

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