Document Type : Original Article


1 Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

2 Department of Pharmacology, Faculty of Medicine, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran.



This study aimed to compare acute phase proteins in cats undergoing ovariohysterectomy (OHE) by median celiotomy or left flank laparotomy approach. 
Nineteen native intact queens were used. Cats were randomly divided into four groups for midline (Test, n=5 and control, n=5) and left flank (Test, n=5 and control, n=4) ovariohysterectomy. Blood samples were taken immediately before surgery, 24, 48, 72 hours, and 7 days after surgery for assessment of Alpha-1-acid glycoprotein (AGP), total protein, and albumin values. According to the results, standard and left flank OHE approaches increased AGP levels, but no significant difference was observed compared to the control group (p > 0.05). No significant difference was observed on serum total protein and albumin levels using standard and left flank OHE approaches compared to the control group (p > 0.05). The results suggested two surgical procedures had the same effect on acute-phase proteins in ovariohysterectomized cats.


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