Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Effect of N-Acetylcysteine on Acute Hyperglycemia Induced by Urethane in Rats: Role of α2-Adrenergic Receptor 1 8 225235 10.30500/ivsa.2025.512508.1440 EN Nazanin Zahra Rouzkhosh PhD candidate, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0009-0005-5052-3365 Esmaeal Tamaddonfard Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0001-8240-5885 Amir Erfanparast Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0003-2526-2253 Journal Article 2025 03 15 N-acetylcysteine (NAC) is used to treat respiratory, neurodegenerative, and metabolic disorders. In the present study, the effect of NAC was investigated on acute hyperglycemia induced by urethane (URE) in rats. The possible mechanisms including α2-adrenergic receptors and insulin (INS) involvements were explored by intraperitoneal (IP) injection of yohimbine (YOH, an α2-adrenergic receptor antagonist) and determination of serum INS level, respectively. Thirty-five rats were divided into seven groups with equal number to receive IP injections of normal saline (NS), NAC, YOH, and a low dose combination of NAC and YOH before IP injection of URE. Another 20 rats were treated with NS, high doses of NAC, YOH, and their combination without receiving urethane. Time-dependent and percentage alterations in blood glucose level were measured and calculated, respectively. Serum INS level was measured with an enzyme-linked immune-sorbent assay (ELISA) kit and expressed as percentage. Time-dependent and percentage alterations of acute hyperglycemia induced by URE were reduced by 25 and 50 mg/kg NAC, 1 mg/kg YOH, and a combination treatment with low doses of NAC (12.5 mg/kg) and YOH (0.25 mg/kg). The urethane alone did not affect INS percentage, but NAC, YOH, and their combination increased it. Conscious rats showed no significant differences in blood glucose and serum INS levels. It is concluded that NAC produced an anti-hyperglycemic effect. This antihyperglycemic action of NAC might be mediated by α2-adrenergic receptors and pancreatic insulin.

https://www.ivsajournals.com/article_225235_211e151e79e9f66b997c300d62e5c02d.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Effects of Fisetin on Cutaneous Full Thickness Wound Healing in a Rat Model 9 14 223454 10.30500/ivsa.2025.519077.1444 EN Behdad Beheshti Alagha Department of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran. Farshid Davoodi Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. 0000-0003-1420-4306 Rahim Mohammadi Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0002-2104-9829 Seyede Soraya Mahmoudi Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Journal Article 2025 04 25 Cutaneous wound healing is a complex biological process involving inflammation, proliferation, and tissue remodeling. Fisetin, a dietary flavonoid found in fruits and vegetables, is known for its potent antioxidant and anti-inflammatory properties. However, its therapeutic potential in wound healing has not been previously explored. This study aimed to evaluate the effects of topical fisetin on skin wound healing in a rat model. Forty male rats were randomly divided into four groups: control (no treatment), olive oil (vehicle), treatment 1 (T1; 10 mg/kg fisetin in olive oil), and treatment 2 (T2; 20 mg/kg fisetin in olive oil). A full-thickness dorsal wound (20 mm) was created in each rat. Treatments were administered topically for 14 days. Wound contraction was measured on days 3, 6, 9, 12, and 14. Oxidative stress markers malondialdehyde (MDA), Total oxidant status (TOS), superoxide dismutase (SOD), and total antioxidant capacity (TAC) were assessed on day 14, and histological evaluation using H&E staining was performed on days 7 and 14. Fisetin significantly accelerated wound contraction, particularly in the T2 group. MDA and TOS levels were significantly reduced, while SOD and TAC were elevated in fisetin-treated groups compared to controls. Histopathological analysis revealed reduced inflammatory cell infiltration, enhanced collagen deposition, and re-epithelialization, especially in the T2 group. Topical application of fisetin markedly improves cutaneous wound healing by modulating oxidative stress and enhancing tissue regeneration. These findings suggest fisetin as a promising natural agent for promoting skin repair and warrant further investigation in clinical settings.

https://www.ivsajournals.com/article_223454_fee7f6632fb0de383961829ab7f94c06.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Clinical Evaluation of Antibiotic Loaded Calcium Phosphate Beads as Treatment Options for Avian Soft Tissue and Orthopaedic Cases 15 20 226125 10.30500/ivsa.2025.485783.1422 EN Abraham Gabriel Abdullah EL’S Veterinary Centre, Companion and Avian-Exotic Medicine and Surgery, Selangor, Malaysia. 0000-0002-3774-8229 Jalila Abu Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), Selangor, Malaysia. 0000-0002-8953-0977 Journal Article 2024 10 27 The process of wound and fracture healing comprises several stages, some of which necessitate the use of enhancers. The aim of the present study was to assess the efficacy of gentamicin-clindamycin (GEN/CLI) loaded in calcium phosphate (CaP) beads as potential treatment modalities for contaminated wounds and fracture healing in avian patients. Six (6) avian patients of various species with contaminated wounds, open and closed fractures, or lumps requiring surgical intervention were enrolled in the study. The CaP beads were loaded with gentamicin and clindamycin antibiotics before being implanted during surgical procedures. A radiographic and a modified Southampton surgical wound scoring system were used to assess bone fractures and wounds, respectively. All scores were checked for coherence, and the findings were compared across days using the one-way analysis of variance (ANOVA) with the Tukey-Kramer (HSD) test. There were significant differences in the wound healing progression based on the modified Southampton ranking periodically at p < 0.05. The radiographic assessment demonstrated the biocompatibility of CaP beads, which aided in the formation of new bone tissue while causing no adverse effect. The use of GEN/CLI-loaded CaP beads demonstrated promising results in enhancing both wound and fracture healing in avian patients. The treatment was well-tolerated, promoted new bone formation, and showed no adverse effects, indicating good biocompatibility. The statistically significant improvement in healing progression supports the potential of this approach as an effective therapeutic option. Given the current lack of research in this area, especially concerning avian species, the findings highlight the clinical value of GEN/CLI-loaded CaP beads as a suitable and beneficial adjunct in the surgical management of contaminated wounds and fractures in birds, with potential relevance to other animal species facing comparable clinical conditions.

https://www.ivsajournals.com/article_226125_40d689745be64027821e33fdda84e565.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Protective Effects of Royal Jelly on Oxidative Stress and In Vitro Fertilization Outcomes in a Wistar Rat Model of Varicocele 21 26 219446 10.30500/ivsa.2025.504161.1436 EN Ghodrat Ebadimanas Department of Biology Education, Farhangian University, Tehran, Iran. 0000-0002-4287-4406 Gholamreza Najafi Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Ali Shalizar-Jalali Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0002-9811-7754 Journal Article 2025 02 02 Varicocele, characterized by the abnormal tortuosity and dilation of the pampiniform plexus veins in the spermatic cord, is the most common surgically correctable cause of male infertility. This study aimed to evaluate the protective effects of royal jelly on sperm parameters and in vitro fertilization (IVF) outcomes in a rat model of varicocele. Thirty adult male rats were randomly divided into five groups (n = 6): control, varicocele, varicocele with low-dose royal jelly (50 mg/kg), varicocele with medium-dose royal jelly (100 mg/kg), and varicocele with high-dose royal jelly (200 mg/kg). After a 28-day treatment period, malondialdehyde (MDA), total antioxidant capacity (TAC), sperm parameters, and IVF outcomes were assessed. The varicocele group showed significant reductions in TAC, sperm count, motility, viability, and embryonic development outcomes, including zygote formation, two-cell embryos, blastocysts, and hatched embryos, compared to the control group. Royal jelly treatment improved sperm parameters, fertilization rates, and embryo development in a dose-dependent manner. These findings suggest that royal jelly mitigates the adverse effects of varicocele on fertility in rat, likely due to its antioxidant and free radical scavenging properties.

https://www.ivsajournals.com/article_219446_70af2d58cda7210bb92eac0c879afa4e.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Chitosan-Mediated Metformin Delivery Promotes Dose-Dependent Functional Recovery in a Rat Spinal Cord Injury Model 27 34 226347 10.30500/ivsa.2025.528959.1451 EN Erfan Sheikh-Akbarizadeh Department of Veterinary Clinical Sciences, SR.C., Islamic Azad University, Tehran, Iran. Ahmad Asghari Department of Veterinary Clinical Sciences, SR.C., Islamic Azad University, Tehran, Iran. Gholamreza Abedi Cham-Heydari Department of Veterinary Clinical Sciences, SR.C., Islamic Azad University, Tehran, Iran. Pejman Mortazavi Department of Pathobiology, SR.C., Islamic Azad University, Tehran, Iran. Journal Article 2025 06 07 Spinal cord injury (SCI) is a severe condition characterized by primary mechanical damage followed by secondary injury mechanisms, which worsen cellular dysfunction and death. Current treatment strategies remain insufficient in mitigating the full consequences of SCI. Metformin (Met) has demonstrated neuroprotective effects in the central nervous system (CNS), raising interest in its therapeutic potential for SCI. However, whether a chitosan (CH) hydrogel loaded with Met can enhance functional recovery after SCI remains unclear. Wistar rats were divided into five groups: a sham group, an SCI group (negative control, NC), and three groups receiving CH hydrogel containing 10, 50, and 100 mg/kg of Met. Behavioral assessments, including locomotor scoring and sensorimotor function tests, demonstrated that sustained delivery of the metformin-chitosan hydrogel significantly enhanced functional recovery in spinal cord-injured rats compared to untreated controls. Quantitative analysis revealed notable improvements in hindlimb coordination, weight-bearing capacity, and reflex responses, suggesting partial restoration of neural circuitry. Furthermore, the CH/Met hydrogel group exhibited accelerated recovery kinetics, with earlier onset of motor improvements relative to standard treatments. These findings collectively supported the therapeutic efficacy of CH/Met hydrogel in mitigating SCI-related deficits, potentially through its combined neuroprotective and regenerative mechanisms.

https://www.ivsajournals.com/article_226347_b9a29f9e165807aa8ae6464860811fff.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 The Impact of Topical Vitamin D on Wound Healing in Second-Degree Burn Injuries 35 42 231861 10.30500/ivsa.2025.535668.1455 EN Ali Ranjbari Department of General Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. 0009-0001-2082-8521 Hamid Sorya Department of Pharmacology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. Farzaneh Hosseini Gharalari, Department of Pathology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. 0000-0002-7326-2066 Farhad Abbasian Department of General Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. 0009-0000-2095-2963 Journal Article 2025 07 19 The effects of vitamin D may accelerate wound healing and have anti-inflammatory and antioxidant effects. The present study aimed to determine the effect of topical vitamin D on the healing of second-degree burn wounds in Wistar rats. This experimental in vitro study involved a sample of 32 male Wistar rats. Superficial second-degree burns were induced in the hairless back of the animals. They were randomly divided into four equal groups. In the burnt area, no topical treatment was applied in the control group. In the Vaseline group, a petroleum-based ointment was applied twice daily for 14 days. In the vitamin D group, topical vitamin D ointment, specifically 50 micrograms per gram, was applied twice daily, and in the Silver sulfadiazine cream group, silver sulfadiazine cream was applied twice daily for 14 days. To evaluate the efficacy of treatment, four rats in each group were anesthetized on days 0, 7, and 14, and their skin was processed for histological examination. At the end of the study, the area of the wound in the Vaseline group decreased more than other groups (75.02 ± 21.77 cm2) (p = 0.03). The mean wound healing percentage was 38.23 ± 6.53 cm2 in the Vaseline group, 45.61 ± 6.53 cm2 in the vitamin D group, 43.59 ± 3.33 cm2 in the silver group, and 63.58 ± 5.51 cm2 in the control group; the Vaseline group had a significant difference with all three other groups (p < 0.05). In conclusion, vitamin D ointment improved histological changes of tissue components in the process of healing; therefore, the maximal rate of healing was seen in the Vaseline group. These findings suggest that they can be used as topical treatment agents for burn wounds.

https://www.ivsajournals.com/article_231861_82c81a60e32981a35585ce25fadc2362.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Radiographic Anatomy of the Limb Skeleton of the Neurergus kaiseri 43 50 230486 10.30500/ivsa.2025.542477.1461 EN Omid Zehtabvar Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. 0000-0002-4343-4453 Okan Ekim Department of Anatomy, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey. 0000-0002-3322-4161 Soheila Sehatbakhsh Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. 0009-0001-7020-5701 Barbod Safaei-Mahroo Pars Herpetologists Institute, Tehran, Iran. 0000-0002-3365-6546 Yasin Valizadeh Department of Veterinary Clinical Sciences, SR.C., Islamic Azad University, Tehran, Iran. 0009-0002-4096-3277 Arman Shahbazi Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. 0009-0004-1806-3488 Journal Article 2025 08 20 This study investigates the radiographic anatomy of the forelimb and hindlimb skeletons in the critically endangered Kaiser’s Mountain newt (Neurergus kaiseri), an endemic Iranian salamander. Using non-invasive digital mammography (32 kVp, 80 mAs), we analyzed the osteology of 10 adult specimens (5 males, 5 females) to characterize appendicular skeletal features. The scapulocoracoid was a single bony unit with a prominent glenoid cavity and supracoracoid foramen. The humerus exhibited flattened cranial and caudal crests, while the radius and ulna remained separate, with distinct proximal/distal width patterns. The carpus comprised seven bones (ulnare, radiale, prepollicis, centrale, distal carpals 3–4, and basale commune), and the manus displayed four digits with a phalangeal formula of 2-3-2-2. The pelvic girdle fused into an ilium-ischiopubic plate, lacking an obturator foramen. The femur was longer than the humerus, featuring a medially oriented head and a hook-shaped trochanter. The tibia and fibula were equal in length but shorter than the femur. The pes had five digits (phalangeal formula: 2-2-3-3-2) and seven tarsal bones, including a fused basale commune (distal tarsals 4–5). Comparative analysis revealed key differences from related species (Hynobius setouchi, Batrachuperus londongensis), such as carpal/tarsal bone counts and fusion patterns. These findings provide foundational data for ecological, evolutionary, and conservation studies, highlighting mammography as a viable, non-invasive tool for skeletal research in delicate amphibians.

https://www.ivsajournals.com/article_230486_b75bfdb350109660d883523def499806.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 The Study of the Protective Effects of Fargesin on Experimental Ischemia-Reperfusion Injury of Liver in Male Rats 51 56 225234 10.30500/ivsa.2025.499547.1434 EN Amir Firouz Firouzi Department of Pathobiology, TaMS.C., Islamic Azad University, Tabriz, Iran. 0009-0005-0836-4110 Yousef Doustar Department of Pathobiology, TaMS.C., Islamic Azad University, Tabriz, Iran. 0000-0002-2563-0119 Mohamad Amin Nazari Department of Pathobiology, TaMS.C., Islamic Azad University, Tabriz, Iran. 0009-0006-5134-7268 Daryoush Mohajeri Department of Pathobiology, TaMS.C., Islamic Azad University, Tabriz, Iran. Journal Article 2025 01 14 Reperfusion following ischemia can lead to metabolic and structural damage to the liver. Fargesin, known for its anti-inflammatory properties, holds potential applications in the development of drugs targeting inflammatory disorders. Most recent studies on fargesin have focused on its anti-inflammatory effects. This study aimed to evaluate the effects of fargesin on liver function, as well as its antioxidant and inflammatory status, following the induction of ischemia-reperfusion injury in the liver of rats. For this purpose, 40 male Wistar rats were randomly divided into four groups of 10: (1) Sham group: rats without any surgical intervention, (2) Surgical control group: rats subjected to surgery without ischemia-reperfusion, (3) Ischemia-reperfusion group: rats exposed to ischemia followed by 45 minutes of reperfusion, and (4) Ischemia-reperfusion with fargesin treatment group: rats that received fargesin at a dose of 50 mg/kg P.O via gavage for 12 weeks post-ischemia. Blood and liver tissue samples were collected, and the animals were sacrificed. Levels of serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase were measured. In the liver tissue homogenates, levels of malondialdehyde and the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were assessed. Histopathological examination of liver tissue was performed using light microscopy. In group 4, fargesin significantly (p < 0.05) reduced elevated levels of liver damage marker enzymes, decreased lipid peroxidation, and restored diminished antioxidant levels in the liver. Additionally, histopathological changes in the livers of fargesin-treated rats were significantly ameliorated. The results suggest that fargesin, with its anti-inflammatory properties, exhibits protective effects against ischemia-reperfusion-induced liver injury and could be a potential therapeutic agent for managing ischemia-reperfusion-related liver damage.

https://www.ivsajournals.com/article_225234_9595b3c0a0252f81cf2b607e6a24d206.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Molecular Comparison of Different Types and Antibiotic Resistance Profile of Staphylococcus aureus Isolated from Infected Wounds 57 62 219500 10.30500/ivsa.2025.510172.1438 EN Mohammad Reza Shahmohammadi Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Amir Tukmechi Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0003-3080-4723 Journal Article 2025 03 03 Staphylococcus aureus is one of the most prevalent microorganisms in both medical and veterinary field. This bacterium often could infect in areas of damaged skin, such as abrasions and open wound. This research aims to detect the common type and antibiotic resistant pattern of isolated S. aureus in wound specimens. One hundred and fifty wound swabs were collected from human, sheep and goat (50 equal samples) in West and East Azarbaijan provinces (Iran). All swabs' samples were transferred to the laboratory in peptone water broth near ice box. The samples were cultured aerobically on sheep blood agar medium at 37 °C for 24 h. Then polymerase chain reaction was used for amplification 16S rRNA and mecA genes to identify the S. aureus and methicillin-resistant S. aureus (MRSA). Then antimicrobial susceptibility test was done for antibiotic resistant patterns configuration using some antibiotic discs. S. aureus was isolated from 19 wound samples and 6 isolates were identified as methicillin-resistant S. aureus. The higher and lower isolate was belonged to human (52 %) and goat (8%), also 40 % of sheep wound samples were infected by S. aureus. No animal wound samples had MRSA while six human specimens were infected by MRSA. All isolates were sensitive against cefepime, imipenem and carbapenem and the higher resistances were seen against penicillin, vancomycin and cefazolin. It's concluded that MRSA is common in infected human wound and today new generation of cephalosporins are useful for treatment of many multidrug resistant bacteria.

https://www.ivsajournals.com/article_219500_9c2f2fa98254c048dacbb16ef1ae1a2c.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Protective Effects of Nano-Propolis Liposomes on Iischemia-Reperfusion Injury: A Rat Model of Testicular Torsion and Detorsion 63 70 237400 10.30500/ivsa.2025.548473.1467 EN Mehran Mohammadpour Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Rahim Mohammadi Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0002-2104-9829 Vahid Mohammadi Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0001-8660-4179 Ali Soleimanzadeh Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0002-1591-2198 Journal Article 2025 09 21 A rat testis model was used to assess the effects of nano-propolis liposomes on ischemia-reperfusion injury. Twenty-four healthy male Wistar rats were included and randomised into six investigational groups (n = 6): Group SHAM: only laparotomy was implemented. Group ISCHEMIA: only a 3-hour ischemia was induced. Group IS/REP: A 3-hour ischemia followed by 3 hours reperfusion for the left testis and one week reperfusion for the right testis was performed with 1 ml normal saline that was gavaged 1 hour before the onset of ischemia. Group IS/REP/NPL: As in group IS/REP, but with 1 ml nano-propolis liposomes gavaged 1 hour before the onset of ischemia. Evaluations were based on biochemical analyses and sperm parameters. Propolis enhanced antioxidant activity and quality of sperm parameters (p < 0.05). Nano-propolis liposomes could help minimize ischemia-reperfusion injury in testicular tissue exposed to ischemia.

https://www.ivsajournals.com/article_237400_6fac8701204f0f72c1ab8b46853aa8a8.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Surgical Removal of Nasopharyngeal Polyp in a DSH Cat 71 74 233919 10.30500/ivsa.2025.540437.1458 EN Zahra Shamsi Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Mehdi Behfar Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0001-9046-5677 Mohammad Akbari Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Dara Azizi Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Reza Azargoun Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0002-5442-5552 Seyed Mohammad Hashemi-Asl Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 0000-0003-3909-2144 Seyede Soraya Mahmoudi Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Journal Article 2025 08 10 Feline nasopharyngeal polyps are benign, pedunculated, inflammatory lesions typically originating from the mucosa of the nasopharynx, auditory tube, or tympanic bulla. These polyps predominantly affect cats younger than three years of age and present with upper respiratory and vestibular symptoms. This case report describes a 15-month-old male domestic shorthair cat suffering from progressive respiratory distress, stridor, and dyspnea. Radiographic imaging revealed a soft tissue mass posterior to the soft palate, in the nasopharyngeal region. Following a thorough diagnostic evaluation, surgical removal of the polyp was performed. Histopathological examination of the excised mass revealed a suppurative granuloma composed primarily of neutrophilic infiltration and fibrous stroma. The patient, after a year's follow-up, had no signs and no clinical sign of recurrence. The present case emphasizes the importance of accurate diagnosis, the value of complete surgical excision, and long-term monitoring to detect potential recurrence. Surgical management is the choice treatment for nasopharyngeal polyps, and outcomes are generally favorable when performed with appropriate technique and follow-up care.

https://www.ivsajournals.com/article_233919_255926f0b1700ce42bf0d13116f6ff55.pdf

Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 21 1 2026 04 01 Extradural Vertebral Chondrosarcoma in a Poodle-Terrier Dog 75 78 233920 10.30500/ivsa.2025.541732.1460 EN Ahmad Khajeh Mahrooyan Veterinary Clinic, Ahvaz, Iran. Mahan Sarebani Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Sina Mahmoudabadi Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. 0000-0003-1667-2541 Annahita Rezaie Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Mahnush Kamyabnia Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Elham Eslahi Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University of Shoushtar, Shoushtar, Iran. Journal Article 2025 08 17 This study describes the clinical presentation, magnetic resonance imaging (MRI) features, surgical treatment, and outcome of an unusual extradural vertebral chondrosarcoma in a dog. A 6-year-old neutered male Poodle-Terrier with an extradural chondrosarcoma diagnosed at the level of the T11 vertebra, following surgical excision by dorsal laminectomy. Clinical, radiographic, MRI, histopathologic, and postoperative rehabilitation data were assessed. Following the sudden onset of pelvic limb paralysis in the dog, MRI revealed a lobulated, extradural mass at the T11 vertebra (13 × 7 mm) hyperintense on T2-weighted images, causing compression of the spinal cord. Surgical removal revealed a chondrosarcoma with a soft, pale pink to white gross appearance. Rehabilitation following surgery, including physiotherapy, hydrotherapy, and laser therapy, resulted in weight-bearing recovery within 3 months, while the dog never acquired the ability to stand without support until 9 months despite 80 sessions of physiotherapy. No metastasis was observed after surgery. This case exemplifies the diagnostic utility of MRI for detection of extradural spinal tumors and potential surgical resection for improving quality of life, but long-term prognosis can be reserved due to incomplete functional recovery and local aggressiveness of the tumor.

https://www.ivsajournals.com/article_233920_443b4cbf66ccdc00663d65745fe06be8.pdf