Iranian Veterinary Surgery Association (IVSA) Iranian Journal of Veterinary Surgery 2008-3033 14 2 2019 10 01 Evaluation of Possible Beneficial Effect of Tricalcium Phosphate/Collagen (TCP/collagen) Nanocomposite Scaffold on Bone Healing in Rabbits: Biochemical Assessments 162 172 94132 10.22034/ivsa.2019.193769.1189 EN Hanieh Farahi Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Science And Research Branch, Islamic Azad University, Tehran, Iran Siamak Mashhadi-Rafie Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Science And Research Branch, Islamic Azad University, Tehran, Iran Alireza Jahandideh Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran. 0000-0002-4212-6416 Ahmad Asghari Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran. Seyed Hamed Shirazi-Beheshtiha Department Of Clinical Sciences, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran Journal Article 2019 07 10 <strong>Objective-</strong> The aim of this study was to evaluate possible beneficial effect of tricalcium phosphate/collagen (TCP/collagene) nanocomposite scaffold on bone healing in rabbits using biochemical assessments<br /><strong>Design-</strong> Experimental study<br /><strong>Animals-</strong> Twelve healthy male white New Zealand rabbits<br /><strong>Procedures-</strong> The rabbits were marked with non-toxic color and randomly divided into two groups of 6 animals each. In the first group (SHAM) the defect was made and with no treatment the wound was closed. In the second group (TCP/C) the tricalcium phosphate/collagen (TCP/collagene) nanocomposite scaffold was implanted into the defect. Before the procedures (day 0) and on 7, 15, 30, 45 and 60 postoperative days the blood samples were taken from jugular vein and undergone hematological and biochemical assessments.<br /><strong>Results- </strong>The hematological, biochemical and oxidative stress parameters including WBC, RBC, HCT, PLT, neutrophil, lymphocytes, BUN, Creatinine, AST, ALT, ALP, SOD, GPX and MDA showed statistically significant differences between Sham and TCP/C groups (<em>p</em><0.05).<strong>    </strong><br /><strong>Conclusion and clinical relevance</strong>- It was concluded that TCP/collagen nanocomposite improved the biochemical parameters in the nanocomposite treated animals and could be of clinical benefit in reconstruction of bone defects and could be considered as a scaffold in bone fractures. https://www.ivsajournals.com/article_94132_5a4591165b125d6d8e17f1e1910d3c8c.pdf