%0 Journal Article %T Histopathological and Serum Enzyme Changes of Propofol Combined with Pre-Anesthetic Agents in Domestic Pigeons (Columba livia) %J Iranian Journal of Veterinary Surgery %I Iranian Veterinary Surgery Association (IVSA) %Z 2008-3033 %A Mousavi, Amirabbas %A Abedi, Gholamreza %A Jahandideh, Alireza %A Hesaraki, Saeed %D 2019 %\ 10/01/2019 %V 14 %N 2 %P 105-115 %! Histopathological and Serum Enzyme Changes of Propofol Combined with Pre-Anesthetic Agents in Domestic Pigeons (Columba livia) %K Metamizole %K Propofol %K Midazolam %K Pigeon anesthesia %K Pathology %R 10.22034/ivsa.2019.173611.1177 %X Objective- Because of the several differences between avian and mammalian physiology and anatomy, avian anesthesia requires to be more attentive. The aim of this study was to determine a safe injectable anesthetic agent that had more compatibility with the avian features.Design- Experimental studyAnimals- Twelve male pigeonsProcedure- The pigeons weighing 302±35 g (mean±SD) were divided into two groups (n=6). In group 1, midazolam (6 mg/kg,-IM) and in group 2, metamizole (500 mg/kg,-IM) were administrated as the pre-anesthetic agents and thereafter, propofol (8 mg/kg,-IV) was injected as the main anesthetic drug in both groups. The serum enzymatic changes were analyzed before and 1 hour after the last injection. Histopathological examinations of the liver and kidneys were also evaluated in terms of possible damages to the tissue.Results- The results of blood biochemistry evaluation in group 1 showed significant changes in the levels of AST and LDH before and after the injections (p<0.05). Histopathology results revealed significant changes in liver parameters in both groups. However, these changes were seen more prominent in group 1 (p<0.05). Also, none of the drugs of both groups had a negative impact on the kidney tissue (p>0.05).Conclusion and clinical relevance- Based on the results, metamizole and propofol combination showed that is safer than midazolam and propofol in terms of blood biochemical and histopathological evaluations and is more compatible with pigeons. %U https://www.ivsajournals.com/article_92076_81653ea0b24ad943fa3f391d0c67b889.pdf