@article { author = {Jeyrani Moghaddam, Amidreza and Kazemi, Davoud}, title = {Evaluating the Feasibility of Esophagotomy Suture Line Reinforcement Using Platelet Rich Fibrin Membrane and is Effect on Wound Healing}, journal = {Iranian Journal of Veterinary Surgery}, volume = {11}, number = {1}, pages = {9-15}, year = {2016}, publisher = {Iranian Veterinary Surgery Association (IVSA)}, issn = {2008-3033}, eissn = {2676-6299}, doi = {}, abstract = {Objective- This study aimed to evaluate the feasibility of using platelet rich fibrin membrane as a novel on-lay patching biomaterial in canine esophagotomy and its effects on esophageal wound healing.Design- Experimental study.Animals- Eight adult mixed breed dogs of both sexes equally allocated to control and treatment groups.Procedures- Longitudinal incisions measuring 3 cm were made in the cervical esophagus of all dogs (2 incisions in each dog). All incisions were sutured and on-lay patching was performed in four dogs using platelet rich fibrin. After 28 days, wound healing was assessed by macroscopic, histological and biochemical methodsResults- Patching resulted in less adhesion formation (18.24 vs. 61.67 mm, p<0.05) and increase in tissue hydroxyproline content (91.31 vs. 74.31 mg, p>0.05). Histologically, platelet rich fibrin membrane mostly influenced wound healing in the outer layers of the esophagus particularly the muscular layer although a slightly better wound healing was observed overall.Conclusion and Clinical Relevance- Platelet rich fibrin membrane could be used as an alternative patching biomaterial in esophageal surgery although further investigations needs to be carried out particularly in clinical cases.}, keywords = {Platelet rich fibrin membrane,Onlay patching,esophagus,Dog,wound healing}, url = {https://www.ivsajournals.com/article_41015.html}, eprint = {https://www.ivsajournals.com/article_41015_b1c93d55716921cee407f49aca19ee3c.pdf} }