Document Type: Original Article

Authors

1 Department of clinical sciences, Faculty of specialized veterinary sciences, Science and research branch, Islamic Azad University, Tehran, Iran

2 Department of pathobiology, Faculty of specialized veterinary sciences, Science and research branch, Islamic Azad University, Tehran, Iran

Abstract

Objective- Because of the several differences between avian and mammalian physiology and anatomy, avian anesthesia requires to be more attentive. The aim of this study was to determine a safe injectable anesthetic agent that had more compatibility with the avian features.
Design- Experimental study
Animals- Twelve male pigeons
Procedure- The pigeons weighing 302±35 g (mean±SD) were divided into two groups (n=6). In group 1, midazolam (6 mg/kg,-IM) and in group 2, metamizole (500 mg/kg,-IM) were administrated as the pre-anesthetic agents and thereafter, propofol (8 mg/kg,-IV) was injected as the main anesthetic drug in both groups. The serum enzymatic changes were analyzed before and 1 hour after the last injection. Histopathological examinations of the liver and kidneys were also evaluated in terms of possible damages to the tissue.
Results- The results of blood biochemistry evaluation in group 1 showed significant changes in the levels of AST and LDH before and after the injections (p<0.05). Histopathology results revealed significant changes in liver parameters in both groups. However, these changes were seen more prominent in group 1 (p<0.05). Also, none of the drugs of both groups had a negative impact on the kidney tissue (p>0.05).
Conclusion and clinical relevance- Based on the results, metamizole and propofol combination showed that is safer than midazolam and propofol in terms of blood biochemical and histopathological evaluations and is more compatible with pigeons.

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