The present study was conducted to evaluate the wound healing effects of liposome nanocarrier containing Scrophularia striata extract. Seventy-two male Wistar albino rats were divided into 6 groups of 12 animals each. Rats were anesthetized, and dorsum shaved. A 100 g cylindrical copper rod of 1cm diameter was heated up to 100° C. It was placed on the skin without any pressure. Histopathological evaluation and the macroscopic size processing and analysis of the burn were employed to study the potential of wound healing in study groups. The study groups were: positive control group (zinc oxide treatment), treatment group (ointment containing nanoliposomes loaded with extract Scrophularia striata), extract group (ointment containing hydroalcoholic extract Scrophularia striata), control group of nanoliposomes (ointment containing Nano liposomes), Eucerin control group (ointment containing Eucerin), negative control group (no treatment). On the 5th, 10th, and 15th days after the initial operation, samples were taken from 4 rats of each group. The results showed that loaded nanoliposomes had a nanometric size and spherical morphology. Also, the wound size of the treatment group was smaller than other groups and had the best effect on repairing wound healing. Also, in other groups, positive control had a better effect on wound repair than extract, Eucerin, nano, and negative groups. According to the highest re-epithelialization, granulation tissue formation, and the lowest necrotic tissue, we could suggest that the treatment group had the best healing effect among other groups.