Document Type : Short Communication

Authors

1 Department of Clinical Sciences, School of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.

2 D.V.M, School of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.

Abstract

Objective- The aim of the present study was to assess the effect of Nigella sativa oil on prostate dimensions in adult dogs.
Design- Experimental study
Animals- Five adult male dogs
Procedures- In this research, 5 adult male Iranian mixed-breed dogs with a mean age of 7.30 ± 2.77 years and a mean weight of 27 ± 5.7 kg with clinical symptoms of prostatitis were selected. Sagittal and transverse ultrasound images were performed by using a 5 MHZ convex transducer.
Results- In the obtained images desired parameters such as length, width, and height of the prostate gland were measured before and after administration of Nigella sativa. Results showed significant differences between all measured parameters before and after drug administration (p < 0.05).
Conclusion and Clinical Relevance- This study confirms that Nigella sativa oil can reduce prostatic dimensions in adult male dogs. So, it can be used as a safe and effective drug for the treatment of prostate-related diseases such as benign prostatic hyperplasia in dogs.

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Srinivasan K. Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects. Food Quality and Safety, 2018; 2(1): 1–16.

Ali BH, Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother Research, 2003; 17: 299–305.

Debiak, P., Balicki, I. Diagnostic imaging of the canine prostate gland subject to its location and size. Bulletin of the Veterinary Institute in Pulawy, 2009; 53: 313-317.

Berry SJ, Coffey DS, Ewing LL. Effects of aging on prostate growth in beagles. American Journal of Physiology, 1986; 250: 1039-1046.

Zohil AM, Castellano C. Prepubic and transrectal ultrasonography of the canine prostate: A comparative study. Veterinary Radiology & Ultrasound, 1995; 36: 393-396.

Lévy X, Niżański W, von, Heimendahl A, Mimouni P. Diagnosis of common prostatic conditions in dogs: an update. Reproduction in Domestic Animals, 2014; 49: 50-57.

Atalan G, Holt PE, Barr FJ, Brown PJ. Ultrasonographic estimation of prostatic size in canine cadavers. Research in Veterinary Science, 1999; 67: 7-15.

Padmaa MP. Nigella sativa– A comprehensive review, Indian Journal of Natural Products and Resource, 2010; 1(4): 409-429.

Konrad L, Müller HH Lenz C. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Medica, 2000; 66(1): 44-47.

Ruel Y, Barthez PY, Mailles A, Begon D. Ultrasonographic evaluation of the prostate in healthy intact dogs. Veterinary Radiology and Ultrasound, 1998; 39(3): 212-216.

Atalan G, Barr FJ, Holt PE. Comparison of ultrasonographic and radiographic measurements of canine prostate dimensions. Veterinary Radiology and Ultrasound, 1999; 40: 408-412. 

Ghadiri A, Avizeh R, Baniadam A, Ranjbar A. comparison of transabdominal and transrectal ultrasonography of the prostate gland in dogs. Iranian Journal of Veterinary Surgery, 2013; 8(2): 43-48.

Vali R. Ultrasonographic measurements of prostatic dimensions in adult Iranian mix breed dogs. Journal of Alternative Veterinary Medicine, 2018; 2(5): 266-272.