TY - JOUR ID - 5789 TI - Efficacy of Different Antiemetics with Different Mechanism of Action on Xylazine Induced Emesis in Cats JO - Iranian Journal of Veterinary Surgery JA - IVSA LA - en SN - 2008-3033 AU - Kolahian, Saeed AD - Assistant Professor in Pharmacology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Iran Y1 - 2014 PY - 2014 VL - 09 IS - 1 SP - 9 EP - 16 KW - Emesis KW - Cat KW - Xylazine KW - Antiemetic DO - N2 - Xylazine hydrochloride, α2 adrenoceptor agonist, is an analgesic, sedative, tranquilizer, and muscle relaxant agent in veterinary medicine which is mostly used as in pre-anesthesia in veterinary medicine. One of the main adverse effects of xylazine which limits application of this medication in small animal veterinary practice (mostly in cats) is nausea and vomiting which can end up with aspiration pneumonia. In this review, we will discuss the efficacy of prophylactic administration of different antiemetics with different mechanism of action in preventing vomiting in cats treated with xylazine hydrochloride. All medications such as acepromazine, promethazine, metoclopramide, ondansetron, dexamethasone, maropitant and vitamine B6 have been shown to have antiemetic efficacy on xylazine induced emesis in cats. These mentioned medications have different antiemetic mechanism of actions. It can be concluded that all these medications not only inhibit α2 adrenoceptor but also may exert their antiemetic effects directly on nucleus tractus solitarius and vomiting center. UR - https://www.ivsajournals.com/article_5789.html L1 - https://www.ivsajournals.com/article_5789_6e9336886fafc7a62f1c710ade9bc1ef.pdf ER -