TY - JOUR ID - 41017 TI - Evaluating the Effects of Enrofloxacin on Angiogenesis Using the Chick Embryo Chorioallantoic Membrane Model JO - Iranian Journal of Veterinary Surgery JA - IVSA LA - en SN - 2008-3033 AU - Tavakkoli, Hadi AU - Tajik, Javad AU - Zeinali, Mahdi AD - Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran AD - Student of Veterinary Medicine, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran Y1 - 2016 PY - 2016 VL - 11 IS - 1 SP - 17 EP - 22 KW - Angiogenesis KW - Chorioallantoic membrane KW - enrofloxacin DO - N2 - Objective- Because little information was available in the literature about the angiogenic property of enrofloxacin, this investigation was undertaken to evaluate this aspect using an in vivomodel.Design- Experimental study.Animals- Twenty fertile chicken eggs (Ross 308) with the average egg-weight of 55 ± 0.4 g were randomly divided into experimental and control groups.Procedures- Agar pellets were prepared with enrofloxacin concentrations at a dosage of 10 mg/Kg egg-weight. A window was carved on the eggshell and drug-impregnated pellet applied on day 8 of incubation on the surface of the chick chorioallantoic membrane. The response of vascular plexus to the drug application was evaluated.Results- Our results showed that enrofloxacin decrease angiogenesis as shown by a reduction in the morphometric parameters of vascular plexus including total vessel's length, the number of vascular branch, vascular complexity and capillary density (p<0.05).Conclusion and Clinical Relevance- Based on findings, it is suggested that enrofloxacin offer a new class of anti-angiogenic agents that might augment the drugs available for the clinical treatment of angiogenesis related diseases. UR - https://www.ivsajournals.com/article_41017.html L1 - https://www.ivsajournals.com/article_41017_1362837c15051df2ab40a8470f87a7a4.pdf ER -