TY - JOUR ID - 151959 TI - Effect of Cinnamon Nanoparticles in Presence of HAMLET on the Healing of Wounds Infected with Pseudomonas aeruginosa: An Animal Model Study JO - Iranian Journal of Veterinary Surgery JA - IVSA LA - en SN - 2008-3033 AU - Ramezani, Ali AU - Najafpour, Alireza AU - Farahpour, Mohammad Reza AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran. Y1 - 2022 PY - 2022 VL - 17 IS - 2 SP - 130 EP - 135 KW - Cinnamon nanoparticles KW - Wound KW - Infection KW - Pseudomonas aeruginosa KW - Rat DO - 10.30500/ivsa.2021.294467.1269 N2 - The objective was to evaluate the ability of cinnamon nanoparticles (CNPs) in the healing of wounds with Pseudomonas aeruginosa (PAE) infection as well as HAMLET sensitization in rats. Fifty healthy male Wistar rats were used in this study. The rats were divided into 5 groups (n = 10), randomly. In the NORMAL group, no infected wounds were treated with a sterile solution of saline 0.9% (0.1 ml). In the PAE group, the wounds with Pseudomonas aeruginosa infection were only treated with a sterile solution of saline 0.9% (0.1 ml). In the PAE-HMLT group, HAMLET (100 µg) was used to treat infected wounds. In the PAE-CNM group, 1 mg/ml CNPs (0.1 ml) were applied topically to treat PAE-infected wounds. In the PAE-HMLT-CNM group, HAMLET (100 µg) and 1 mg/ml CNPs (0.1 ml) were applied topically to treat PAE-infected wounds. Microbiological examination, planimetric and biochemical showed a significant difference between rats in the PAE-HMT-CNM group in comparison with other groups (p < 0.05). In conclusion, CNPs could offer the potential to pay more attention to this harmless and easily available agent to be topically applied in wounds with infection. UR - https://www.ivsajournals.com/article_151959.html L1 - https://www.ivsajournals.com/article_151959_63ea839594f4357eaabeaf9ee8f755f4.pdf ER -