TY - JOUR ID - 126718 TI - Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat JO - Iranian Journal of Veterinary Surgery JA - IVSA LA - en SN - 2008-3033 AU - Sadat-Hosseini, Seyed Mohammad Ali AU - Moslemi, Hamid Reza AU - Nourbakhsh, Mohammad Sadegh AU - Ghaffari-Khaligh, Sahar AD - DVM Graduated, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. AD - Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran. AD - Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. Y1 - 2021 PY - 2021 VL - 16 IS - 1 SP - 12 EP - 18 KW - Eucalyptus extract KW - Electrospinning KW - polyvinyl alcohol KW - Achilles tendon KW - Rat DO - 10.30500/ivsa.2021.262669.1237 N2 - Injury and degeneration of tendons can be highly debilitating and can result in substantial pain, disability, and healthcare costs. Nano-sized fibers have a much wider surface area than conventionally produced fibers, which can hold composite materials more compactly and thus provide greater mechanical capabilities. In this study, the injured tendon was treated by electrospun PVA mats containing eucalyptus extract and histopathological results of healing were evaluated. For this study, 45 male Wistar rats were prepared and a partial thickness tenotomy was created on right hindlimbs. All rats were divided into three groups (n = 15) and three sub-groups (n = 5) including, eucalyptus extract-loaded nanofibers, PVA nanofibers, and without any treatment as a control group. Histological samples were taken on days 14, 28, and 42. The histological analysis on day 14 indicated no significant difference was observed between all groups (p  > 0.05). While on days 28 and 42 post-rupture indicated a higher regenerating activity and capacity in the eucalyptus extract-loaded nanofibers than PVA nanofiber and control groups (p  ≤ 0.05). In summary, these results suggest that the eucalyptus extract-loaded nanofibers mats promoted the healing process of damaged Achilles tendon in rats. UR - https://www.ivsajournals.com/article_126718.html L1 - https://www.ivsajournals.com/article_126718_e21b611e6bf93d4eebd9f893ad880d34.pdf ER -