%0 Journal Article %T Benidipine Reduces Ischemia/Reperfusion Injury Following Testicular Torsion/Detorsion in Rats %J Iranian Journal of Veterinary Surgery %I Iranian Veterinary Surgery Association (IVSA) %Z 2008-3033 %A Javanmardi, Sara %A Khordadmehr, Monireh %D 2017 %\ 12/01/2017 %V 12 %N 2 %P 21-30 %! Benidipine Reduces Ischemia/Reperfusion Injury Following Testicular Torsion/Detorsion in Rats %K Benidipine %K ischemic – reperfusion %K testicular torsion %K Rat %R 10.22034/ivsa.2017.97394.1128 %X Objective-This study aimed to determine the protective effects of benidipine on testicular injury after testis torsion/detorsion in ratsDesign-Experimental studyAnimals-Fifteen male Sprague-Dawly rats weighing 200-220gProcedure-Rats were randomly divided into 3 groups: sham (healthy group with sham operation, n=5), IRC group (control group in which I/R injury was performed by torsion the right testis 720 º clockwise for 2 hours and detorsion for 2 hours, n=5), and IRB group (IR + benidipine, I/R process was performed following orally benidipine administration + 4 mg/kg benidipine, n=5). Levels of glutathione peroxidase (GPx) and malondialdehyde (MDA) were determined in testicular tissues of rats. Testicular tissues were also examined histopathologically. Results-The levels of MDA (P<0.0001) was significantly increased augmented in the testis of IRC group rat. Testicular GPx levels were significantly reduced (p<0.0001) after I/R. Administration of benidipine before torsion prevented the increase in lipid peroxidation and alleviated GPx levels. Benidipine also impeded ischemia/reperfusion cellular damage and histological alternations in testicular tissueConclusion and clinical relevance-These results show that therapy with benidipine before torsion may induce protective effects against ischemia/reperfusion injury %U https://www.ivsajournals.com/article_57466_360395da0d827c60bc1dff296261e924.pdf