@article { author = {Javadi-Afshar, Ali and Najafpour, Alireza}, title = {Effect of Systemic Administration of Curcumin on Ischemia-Reperfusion Injury in Ovaries: An Animal Model Study}, journal = {Iranian Journal of Veterinary Surgery}, volume = {14}, number = {1}, pages = {1-8}, year = {2019}, publisher = {Iranian Veterinary Surgery Association (IVSA)}, issn = {2008-3033}, eissn = {2676-6299}, doi = {10.22034/ivsa.2019.154065.1164}, abstract = {Objective-Ovarian torsion must be diagnosed and treated as much early as possible. The aim of the present study was to investigate effects of interaperitoneal administration of curcumin on ischemia-reperfusion injury in ovaries.Design- Experimental StudyAnimals- Twent-four healthy female Wistar ratsProcedures- Twent-four healthy female Wistar rats weighing approximately 260g were randomized into four experimental groups (n = 6): Group Sham: The rats underwent only laparotomy. Group I: A 3- hour ischemia only. Group I/R: A 3-hour ischemia and a 3-hour reperfusion. Group I/R/C: A 3-hour ischemia, a 3-hour reperfusion and 1 mg/kg interaperitoneal administration of curcumin 2.5 hours after induction of ischemia. Results-Curcumin treated animals showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (P<0.05). The significant higher values of SOD, GPO and GST were observed in I/R/C animals compared to those of other groups (P<0.05). The damage indicators (MDA) was significantly lower in I/R/C animal compared to those of other groups (P<0.05).Conclusion and Clinical Relevance- Interaperitoneal administration of curcumin could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.}, keywords = {ischemia-reperfusion,curcumin,Intraperitoneal,Ovary}, url = {https://www.ivsajournals.com/article_82774.html}, eprint = {https://www.ivsajournals.com/article_82774_06a32e1d1f99ac76b831241d9f10c664.pdf} }